Physicochemical characterization of zofenopril inclusion complex with hydroxypropyl-β-cyclodextrin

Solid State Characterization of Domperidone: Hydroxypropyl-β-Cyclodextrin Inclusion Complex

The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-β-cyclodextrin in order improved the solubility and hence to increase dissolution of domperidone. An effect of concentration of hydroxylpropyl-β-cyclodextrin on the aqueous solubility of domperidone was determined by phase-solubility method. The aqueous solubility of domperidone increased as a f...

NMR spectroscopic characterization of β- cyclodextrin inclusion complex with vanillin

Proton magnetic resonance ((1)HNMR) spectroscopy and physicochemical studies of zaleplon-hydroxypropyl-β-cyclodextrin inclusion compounds.

Proton magnetic resonance spectroscopy ((1)HNMR) studies on inclusion compounds of zaleplon with hydroxypropyl-β- cyclodextrin (HPβCD) were carried out in order to elucidate the strength and binding mode of association. Chemical shift measurements revealed that inclusion complexes of zaleplon and HPβCD were formed by penetration of aromatic rings into the HPβCD cavity from the wider rim side wi...

Physicochemical Characterization of Inclusion Complex of Catechin and Glucosyl-β-Cyclodextrin

Purpose: To investigate the suitability of glucosyl-β-cyclodextrin (G-β-CD) to form inclusion complex with catechin, and characterize the physicochemical properties of the inclusion complex of catechin and G-β-CD. Methods: Catechin and G-β-CD was mixed in water at the same molar ratio, stirred at 20 °C for 48 h and lyophilized to obtain the complex. Its physicochemical properties were investiga...

β-Cyclodextrin Inclusion Complex to Improve Physicochemical Properties of Pipemidic Acid: Characterization and Bioactivity Evaluation

The aptitude of cyclodextrins (CDs) to form host-guest complexes has prompted an increase in the development of new drug formulations. In this study, the inclusion complexes of pipemidic acid (HPPA), a therapeutic agent for urinary tract infections, with native β-CD were prepared in solid state by kneading method and confirmed by FT-IR and 1H NMR. The inclusion complex formation was also charac...